Efficacy of irreversible electroporation in human pancreatic adenocarcinoma: advanced murine model
نویسندگان
چکیده
منابع مشابه
Efficacy of irreversible electroporation in human pancreatic adenocarcinoma: advanced murine model
Irreversible electroporation (IRE) is a promising cell membrane ablative modality for pancreatic cancer. There have been recent concerns regarding local recurrence and the potential use of IRE as a debulking (partial ablation) modality. We hypothesize that incomplete ablation leads to early recurrence and a more aggressive biology. We created the first ever heterotopic murine model by inoculati...
متن کاملIrreversible electroporation of locally advanced pancreatic neck/body adenocarcinoma.
OBJECTIVE Irreversible electroporation (IRE) of locally advanced pancreatic adenocarcinoma of the neck has been used to palliate appropriate stage 3 pancreatic cancers without evidence of metastasis and who have undergone appropriate induction therapy. Currently there has not been a standardized reported technique for pancreatic mid-body tumors for patient selection and intra-operative techniqu...
متن کاملTreatment of 200 locally advanced (stage III) pancreatic adenocarcinoma patients with irreversible electroporation: safety and efficacy.
OBJECTIVES Ablative therapies have been increasingly utilized in the treatment of locally advanced pancreatic cancer (LAPC). Irreversible electroporation (IRE) is an energy delivery system, effective in ablating tumors by inducing irreversible membrane destruction of cells. We aimed to demonstrate efficacy of treatment with IRE as part of multimodal treatment of LAPC. METHODS From July 2010 t...
متن کاملAn update on the role of irreversible electroporation in locally advanced pancreatic adenocarcinoma.
Significant treatment challenges remain in near 40% of patients who are diagnosed with stage III locally advanced pancreatic adenocarcinoma. Current standard of care literature has outlined a median overall survival in this sub group of patients of 12–15 months in most current reviews. The use of pancreatic ablation has been reported initially with thermal based modalities such as radiofrequenc...
متن کاملIrreversible electroporation therapy in the management of locally advanced pancreatic adenocarcinoma.
BACKGROUND Locally advanced pancreatic cancer patients have limited options for disease control. Local ablation technologies based on thermal damage have been used but are associated with major complications in this region of the pancreas. Irreversible electroporation (IRE) is a nonthermal ablation technology that we have shown is safe near vital vascular and ductal structures. The aim of this ...
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ژورنال
عنوان ژورنال: Molecular Therapy - Methods & Clinical Development
سال: 2015
ISSN: 2329-0501
DOI: 10.1038/mtm.2015.1